Affleck started out as an actor, making appearances in films and TV shows, such as Wild Thing, Cross Country, Murder By Phone, Visiting Hours, Dirty Tricks, My Bloody Valentine, Scanners, Oh Heavenly Dog and Will There Really Be a Morning?. My Bloody Valentine was his most prominent role.
After struggling to become an actor in Toronto, Affleck moved to Los Angeles in the United States and decided to become an animator. He had been mentored in animation by Norman McLaren at the National Film Board of Canada (NFB). As Affleck's visa was about to expire, a friend informed him that directors were being hired to work on The Simpsons. Affleck worked on The Simpsons from 1994 to 2007, animating 52 and directing seven episodes.