Eklund appeared in two episodes of Blood Ties playing the character of Norman Bridwel, who becomes a demon. In 2006 and 2007, Eklund appeared as Vancouver narcotics detective, Rene Dejardins, in CBC's drama, Intelligence. In 2007, Eklund starred alongside Leelee Sobieski in the 2007 Robert Cuffley film Walk All over Me. That same year, he appeared as a creepy doorman in a scene with Al Pacino in the thriller film 88 Minutes.
In 2008, Eklund starred in the Supernatural series in the episode "Monster Movie", as Ed Brewer. Eklund has also guest starred in Smallville twice (Season 1 as a janitor & Season 6 as a fight ring announcer). In 2009, he had a small role in Terry Gilliam's The Imaginarium of Doctor Parnassus.
In 2010, he made a guest appearance on J.J. Abrams's Fringe in the third season episode "The Plateau" playing Milo, a savant capable of calculating all future possibilities based on patterns. He also played Larry in the comedy-western film Gunless with Paul Gross and appeared in the action movie Hunt to Kill, with Steve Austin in 2010. He also had a small role as Navy Dude in Smokin' Aces 2: Assassins' Ball. In 2011, he starred in Canadian movie Pressed as Jimmy. He starred alongside Michael Biehn in the Xavier Gensthriller The Divide, which screened at the Toronto After Dark Film Festival in 2011.
In 2012, Eklund appeared as the title escapee in the Alcatraz episode "Kit Nelson." He also played the character of Father in the apocalyptic siege warfare film The Day with Dominic Monaghan and Shawn Ashmore. That same year he starred in the film Errors of the Human Body for which he was awarded best actor for the AMD 'Next Wave' Spotlight Competition at Fantastic Fest.
Eklund appeared in the 2013 Brad Anderson film The Call, alongside Halle Berry, Abigail Breslin, Morris Chestnut, and Michael Imperioli. He also appeared in WWE Studios' The Marine 3: Homefront (2013).
Eklund also starred in an episode of the hit CW TV series Arrow in the second season. He also appeared in See No Evil 2 in 2014, a sequel to the WWE Studios produced 2006 film See No Evil. In the same year he co-starred Tony Todd in the Horror western film The Cold Descent. He also played Zane Morgan on the Bates Motel series.