Whigham was born on August 18, 1997 in New York City, New York. Her father is actor Shea Whigham. She had her first break in the acting world starring alongside Ellery Sprayberry in the 2016 short film Pinky. Following on from her acting debut, she won roles on a variety of TV shows including Shameless, Son of Zorn, 13 Reasons Why and The Orville.
In 2017, she co-starred in the film Saving Zoë which is an adaptation to Alyson Noël’s bestselling young adult novel of the same title, alongside starring sisters and actresses, Laura and Vanessa Marano. On September 13, 2017, it was announced that Whigham would join as a series regular in the third season of the MTV slasher television series Scream as Beth.
Most recently she was on Netflix's The Punisher season 2 as Amy Bendix.