She has voiced television characters such as Tommy Pickles in Rugrats and its spin-off All Grown Up!, Buttercup in The Powerpuff Girls, Rudy Tabootie in ChalkZone, and Freefall / Roxy Spaulding in the film Gen and Private Isabel "Dizzy" Flores in Roughnecks: Starship Troopers Chronicles. She provided the voice for the title role in the live action feature film Babe: Pig in the City, replacing Christine Cavanaugh. More recently in 2013 she began doing the voice of Julius Jr. on the self title Nick Jr. television show.
Besides doing voice-overs, Daily has acted in film and on TV. She played Sandy Burns on the PBS series The Righteous Apples from 1980 to 1981. In 1985, she starred as Dottie in the cult classic Pee-wee's Big Adventure as well as Loryn in Valley Girl and as a singer in the cult comedy Better Off Dead. She also appeared on such shows as Laverne & Shirley, CHiPs, Fame and Friends. She was also in the video for Rod Stewart's song "Young Turks" as Patti, one of the runaway teens. In February 2015 she was cast for Rob Zombie's 31 where she will portray Sex-Head, the woman on the side of Torsten Voges, which played Death-Head.