Aimee was cast as Maria on The WB's Greetings from Tucson and appeared in the Global Frequency television pilot as Aleph. She had a role in the Disney Channel original movie Cadet Kelly, and co-starred, as Lydia, alongside Anthony Anderson in The WB sitcom All About the Andersons. In 2006, she began appearing on the series George Lopez, playing Lopez's niece.
Garcia starred alongside Jessica Simpson in the comedy-drama Major Movie Star. She also played a brief part in the movie D-War and narrated the Adam Sandler film Spanglish.
From 2009 to 2010, she was in the cast of the Peter Berg NBC medical drama Trauma, as EMT helicopter pilot Marisa Benez.
Garcia spent three years on Showtime's Dexter as Jamie Batista, for which she was nominated for a SAG Award for Best Ensemble in Dramatic Television Series.
She played Dr. Jae Kim in MGM's reboot film, RoboCop.
In 2016, Garcia was added to the main cast for season two of the Fox TV series Lucifer, playing LAPD forensic scientist Ella Lopez.